1. LiH, HastingsMH, RheeJ, TragerLE, RohJD, RosenzweigA. Targeting age-related pathways in heart failure. Circ Res 2020;126:533-51.
2. López-OtínC, BlascoMA, PartridgeL, SerranoM, KroemerG. Hallmarks of aging: an expanding universe. Cell 2023;186:243-78.
3. CampisiJ. Aging, cellular senescence, and cancer. Annu Rev Physiol 2013;75:685-705.
4. GorgoulisV, AdamsPD, AlimontiA, et al. Cellular senescence: defining a path forward. Cell 2019;179:813-27.
5. MehdizadehM, AguilarM, ThorinE, FerbeyreG, NattelS. The role of cellular senescence in cardiac disease: basic biology and clinical relevance. Nat Rev Cardiol 2022;19:250-64.
6. ShimizuI, MinaminoT. Cellular senescence in cardiac diseases. J Cardiol 2019;74:313-9.
7. AndersonR, LagnadoA, MaggioraniD, et al. Length-independent telomere damage drives post-mitotic cardiomyocyte senescence. EMBO J 2019;38:e100492.
8. LyuG, GuanY, ZhangC, et al. TGF-β signaling alters H4K20me3 status via miR-29 and contributes to cellular senescence and cardiac aging. Nat Commun 2018;9:2560.
9. ZhangFX, ChenML, ShanQJ, et al. Hypoxia reoxygenation induces premature senescence in neonatal SD rat cardiomyocytes. Acta Pharmacol Sin 2007;28:44-51.
10. DookunE, WalaszczykA, RedgraveR, et al. Clearance of senescent cells during cardiac ischemia-reperfusion injury improves recovery. Aging Cell 2020;19:e13249.
11. RedgraveRE, DookunE, BoothLK, et al. Senescent cardiomyocytes contribute to cardiac dysfunction following myocardial infarction. NPJ Aging 2023;9:15.
12. SalernoN, MarinoF, ScaliseM, et al. Pharmacological clearance of senescent cells improves cardiac remodeling and function after myocardial infarction in female aged mice. Mech Ageing Dev 2022;208:111740.
13. Lérida-VisoA, Estepa-FernándezA, Morellá-AucejoÁ, et al. Pharmacological senolysis reduces doxorubicin-induced cardiotoxicity and improves cardiac function in mice. Pharmacol Res 2022;183:106356.
14. MaejimaY, AdachiS, ItoH, HiraoK, IsobeM. Induction of premature senescence in cardiomyocytes by doxorubicin as a novel mechanism of myocardial damage. Aging Cell 2008;7:125-36.
15. SpallarossaP, AltieriP, AloiC, et al. Doxorubicin induces senescence or apoptosis in rat neonatal cardiomyocytes by regulating the expression levels of the telomere binding factors 1 and 2. Am J Physiol Heart Circ Physiol 2009;297:H2169-81.
16. SheekeyE, NaritaM. p53 in senescence - it’s a marathon, not a sprint. FEBS J 2023;290:1212-20.
17. KimS, KimC. Transcriptomic analysis of cellular senescence: one step closer to senescence Atlas. Mol Cells 2021;44:136-45.
18. WechterN, RossiM, AnerillasC, et al. Single-cell transcriptomic analysis uncovers diverse and dynamic senescent cell populations. Aging 2023;15:2824-51.
19. KaleA, SharmaA, StolzingA, DesprezPY, CampisiJ. Role of immune cells in the removal of deleterious senescent cells. Immun Ageing 2020;17:16.
20. SchloesserD, LindenthalL, SauerJ, et al. Senescent cells suppress macrophage-mediated corpse removal via upregulation of the CD47-QPCT/L axis. J Cell Biol 2023;222:e202207097.
21. OvadyaY, KrizhanovskyV. Strategies targeting cellular senescence. J Clin Invest 2018;128:1247-54.
22. MitryMA, LaurentD, KeithBL, et al. Accelerated cardiomyocyte senescence contributes to late-onset doxorubicin-induced cardiotoxicity. Am J Physiol Cell Physiol 2020;318:C380-91.
23. LindersAN, DiasIB, OvchinnikovaES, et al. Evaluation of senescence and its prevention in doxorubicin-induced cardiotoxicity using dynamic engineered heart tissues. JACC CardioOncol 2023;5:298-315.
24. RouhiL, AugusteG, ZhouQ, et al. Deletion of the Lmna gene in fibroblasts causes senescence-associated dilated cardiomyopathy by activating the double-stranded DNA damage response and induction of senescence-associated secretory phenotype. J Cardiovasc Aging 2022;2:30.
25. CuiS, XueL, YangF, et al. Postinfarction hearts are protected by premature senescent cardiomyocytes via GATA 4-dependent CCN 1 secretion. J Am Heart Assoc 2018;7:e009111.
26. ShibamotoM, HigoT, NaitoAT, et al. Activation of DNA damage response and cellular senescence in cardiac fibroblasts limit cardiac fibrosis after myocardial infarction. Int Heart J 2019;60:944-57.
27. FengT, MengJ, KouS, et al. CCN1-induced cellular senescence promotes heart regeneration. Circulation 2019;139:2495-8.
28. SarigR, RimmerR, BassatE, et al. Transient p53-mediated regenerative senescence in the injured heart. Circulation 2019;139:2491-4.
29. MeyerK, HodwinB, RamanujamD, EngelhardtS, SarikasA. Essential role for premature senescence of myofibroblasts in myocardial fibrosis. J Am Coll Cardiol 2016;67:2018-28.
30. SawakiD, CzibikG, PiniM, et al. Visceral adipose tissue drives cardiac aging through modulation of fibroblast senescence by osteopontin production. Circulation 2018;138:809-22.
31. ZhuF, LiY, ZhangJ, et al. Senescent cardiac fibroblast is critical for cardiac fibrosis after myocardial infarction. PLoS One 2013;8:e74535.
32. BirchJ, GilJ. Senescence and the SASP: many therapeutic avenues. Genes Dev 2020;34:1565-76.
33. ChicheA, LeRoux I, vonJoest M, et al. Injury-induced senescence enables invivo reprogramming in skeletal muscle. Cell Stem Cell 2017;20:407-14.e4.
34. DemariaM, OhtaniN, YoussefSA, et al. An essential role for senescent cells in optimal wound healing through secretion of PDGF-AA. Dev Cell 2014;31:722-33.
35. HerranzN, GilJ. Mechanisms and functions of cellular senescence. J Clin Invest 2018;128:1238-46.
36. LiT, MengY, DingP, et al. Pathological implication of CaMKII in NF-κB pathway and SASP during cardiomyocytes senescence. Mech Ageing Dev 2023;209:111758.
37. TamamoriM, ItoH, AdachiS, AkimotoH, MarumoF, HiroeM. Endothelin-3 induces hypertrophy of cardiomyocytes by the endogenous endothelin-1-mediated mechanism. J Clin Invest 1996;97:366-72.
38. ParkH, KimCH, JeongJH, ParkM, KimKS. GDF15 contributes to radiation-induced senescence through the ROS-mediated p16 pathway in human endothelial cells. Oncotarget 2016;7:9634-44.
39. RochetteL, DogonG, ZellerM, CottinY, VergelyC. GDF15 and cardiac cells: current concepts and new insights. Int J Mol Sci 2021;22:8889.
40. RouhiL, CheedipudiSM, ChenSN, et al. Haploinsufficiency of Tmem43 in cardiac myocytes activates the DNA damage response pathway leading to a late-onset senescence-associated pro-fibrotic cardiomyopathy. Cardiovasc Res 2021;117:2377-94.
41. SuarezG, MeyerroseG. Heart failure and galectin 3. Ann Transl Med 2014;2:86.
42. FengJ, LiY, LiY, et al. Versican promotes cardiomyocyte proliferation and cardiac repair. Circulation 2024;149:1004-15.
43. SalottiJ, JohnsonPF. Regulation of senescence and the SASP by the transcription factor C/EBPβ. Exp Gerontol 2019;128:110752.
44. FelisbinoMB, RubinoM, TraversJG, et al. Substrate stiffness modulates cardiac fibroblast activation, senescence, and proinflammatory secretory phenotype. Am J Physiol Heart Circ Physiol 2024;326:H61-73.
45. GevaertAB, ShakeriH, LeloupAJ, et al. Endothelial senescence contributes to heart failure with preserved ejection fraction in an aging mouse model. Circ Heart Fail 2017;10:e003806.
46. KrishnamurthyJ, TorriceC, RamseyMR, et al. Ink4a/Arf expression is a biomarker of aging. J Clin Invest 2004;114:1299-307.
47. KirklandJL, TchkoniaT. Senolytic drugs: from discovery to translation. J Intern Med 2020;288:518-36.
48. WangE. Senescent human fibroblasts resist programmed cell death, and failure to suppress bcl2 is involved. Cancer Res 1995;55:2284-92.
49. ZhuY, TchkoniaT, PirtskhalavaT, et al. The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs. Aging Cell 2015;14:644-58.
50. LindauerM, HochhausA. Dasatinib. Recent Results Cancer Res 2018;212:29-68.
51. KonecnyGE, GlasR, DeringJ, et al. Activity of the multikinase inhibitor dasatinib against ovarian cancer cells. Br J Cancer 2009;101:1699-708.
52. BruningA. Inhibition of mTOR signaling by quercetin in cancer treatment and prevention. Anticancer Agents Med Chem 2013;13:1025-31.
53. GuY, AvolioE, AlvinoVV, et al. The tyrosine kinase inhibitor Dasatinib reduces cardiac steatosis and fibrosis in obese, type 2 diabetic mice. Cardiovasc Diabetol 2023;22:214.
54. ElmadaniM, RaatikainenS, MattilaO, et al. Dasatinib targets c-Src kinase in cardiotoxicity. Toxicol Rep 2023;10:521-8.
55. ChangJ, WangY, ShaoL, et al. Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice. Nat Med 2016;22:78-83.
56. JiaK, DaiY, LiuA, et al. Senolytic agent navitoclax inhibits angiotensin II-induced heart failure in mice. J Cardiovasc Pharmacol 2020;76:452-60.
57. WalaszczykA, DookunE, RedgraveR, et al. Pharmacological clearance of senescent cells improves survival and recovery in aged mice following acute myocardial infarction. Aging Cell 2019;18:e12945.
58. deVos S, LeonardJP, FriedbergJW, et al. Safety and efficacy of navitoclax, a BCL-2 and BCL-XL inhibitor, in patients with relapsed or refractory lymphoid malignancies: results from a phase 2a study. Leuk Lymphoma 2021;62:810-8.
59. Escriche-NavarroB, GarridoE, SancenónF, García-FernándezA, Martínez-MáñezR. A navitoclax-loaded nanodevice targeting matrix metalloproteinase-3 for the selective elimination of senescent cells. Acta Biomater 2024;176:405-16.
60. OmoriS, WangTW, JohmuraY, et al. Generation of a p16 reporter mouse and its use to characterize and target p16high cells in vivo. Cell Metab 2020;32:814-28.e6.
61. WangB, WangL, GasekNS, et al. An inducible p21-Cre mouse model to monitor and manipulate p21-highly-expressing senescent cells in vivo. Nat Aging 2021;1:962-73.
62. BakerDJ, WijshakeT, TchkoniaT, et al. Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders. Nature 2011;479:232-6.
63. FarrJN, SaulD, DoolittleML, et al. Local senolysis in aged mice only partially replicates the benefits of systemic senolysis. J Clin Invest 2023;133:e162519.
64. AmorC, FeuchtJ, LeiboldJ, et al. Senolytic CAR T cells reverse senescence-associated pathologies. Nature 2020;583:127-32.
65. SudaM, ShimizuI, KatsuumiG, et al. Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice. Nat Aging 2021;1:1117-26.
66. TasdemirN, LoweSW. Senescent cells spread the word: non-cell autonomous propagation of cellular senescence. EMBO J 2013;32:1975-6.
